Subependymal hemorrhage (SEH) into germinal matrix

Subependymal hemorrhage or germinal matrix hemorrhage occurs in premature infants with very low birth weight (<1500g). The germinal matrix in the immature brain is located around the lateral ventricles and it contains a fine network of fragile blood vessels, which are sensitive to ischemia and changes in perfusion pressure. Subependymal hemorrhage in premature neonates can be easily assessed by ultrasound and be divided into four grades.

Grade Description
Grade I hemorrhage confined to the germinal matrix
Grade II intraventricular hemorrhage (hemocephalus) without ventricular dilation
Grade III intraventricular hemorrhage (hemocephalus) with ventricular dilation
Grade IV intraventricular rupture with hemorrhage into the surrounding white matter


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