Maximum allowable contrast dose in adults - calculator of MACD

In healthy adult individuals, the maximum allowable volume of intravenous iodine contrast is:
≤300mL (with concentration 300mg I/mL).
In patients with renal insufficiency in particular, the volume of the contrast should be as low as reasonable. However, it should not exceed
440 x weight [kg] / creatinine [µmol/L] mL
5 x weight [kg] / creatinine [mg/dL] mL
(with concentration 300mg I/mL).

Parameter Value Unit
Body weight kg
Concentration of iodine contrast mg I/mL


1. Brown JR, Robb JF, Block CA, Schoolwerth AC, Kaplan AV, O’Connor GT, et al. Does Safe Dosing of Iodinated Contrast Prevent Contrast-Induced Acute Kidney Injury? Circ Cardiovasc Interv. 2010 Aug 1;3(4):346–50.

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