Adams classification of diffuse axonal injury, DAI

Grading of Diffuse Axonal Injury as proposed by Adams et al.

Grade I:

  • axonal injury limited to white matter (grey-white matter interfaces)

Grade II:

  • Grade I + involvement of corpus callosum

Grade III:

  • Grade II + involvement of brainstem


1. Adams JH, Doyle D, Ford I, Gennarelli TA, Graham DI, Mclellan DR. Diffuse axonal injury in head injury: Definition, diagnosis and grading. Histopathology. 1989;15(1):49–59.